20-hydroxyeicosatetraenoic acid

20-hydroxyeicosatetraenoic acid (20-HETE) is a natriuretic eicosanoid. It is derived from omega hydroxylation of arachidonic acid by the cytochrome P450 enzymes CYP4A and CYP4F. It is mitogenic under many circumstances, and inhibition of 20-HETE has been shown to inhibit several types of cell growth including angiogenesis. Synthesis of 20-HETE can be inhibited by HET0016.