N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine

N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine, abbreviated HET0016, is a formamidine compound. It is a chemical inhibitor of the enzyme CYP4A, and thus 20-HETE synthesis. By inhibiting synthesis of 20-HETE, it acts as an angiogenesis inhibitor. HET0016 and derivatives of it have been suggested as potential drugs to fight glioma, a type of brain cancer, as it significantly reduces the growth of U251 cells in vitro.